Biologic agents for asthma treatment

Psoriatic arthritis: treatment strategies using biologic agents.

The traditional management of psoriatic arthritis (PsA) includes NSAIDs, corticosteroids and DMARDs. Advancement in the knowledge of the immunopathogenesis of PsA has been associated with the development of biologic agents which have revolutionized the management of the disease. Among biologics drugs, there are the 4 currently available anti-TNFα blocking agents (etanercept, infliximab, adalimu...

Biologic agents for the treatment of rheumatoid arthritis.

Substantial progress has been made in our understanding of the immune system and immunopathogenesis of rheumatoid arthritis. This knowledge, combined with advances in biotechnology, has resulted in the development of biologic agents to selectively target elements of the immune system participating in the inflammatory response. This article reviews the available data from clinical trials of biol...

Biologic Agents for the Treatment of Systemic Vasculitis

Biologic agents in psoriasis.

This paper reviews the new biologic agents that selectively block the immunologic steps implicated in the pathogenesis of psoriasis. Four strategies have been targeted: reduction of the number of pathogenic T cells; inhibition of T-cell activation and migration; modulation of the immune system; and blockage of the activity of inflammatory cytokines. There are three classes: monoclonal antibodie...

Biologic Agents in the Treatment of Crohn’s Disease

• Objective: To review the role of the biologic agents in therapy for Crohn’s disease, with particular emphasis on efficacy, indications for use, and impact on disease outcomes. • Methods: Qualitative review of the literature and